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A tumor suppressor protein thought to prevent acute myeloid leukemia (AML) can actually promote a particularly deadly form of the disease, researchers have discovered. The study suggests that targeting this protein could be an effective treatment for certain AML patients.
In 1932 T.S. Eliot famously argued, 'Genuine poetry can communicate before it is understood.' But can we really appreciate the musical sound of poetry independent of its literary meaning? Apparently yes. A recent study has shown that the brain displays a positive electrophysiological response when presented with sentences that conform to certain poetic construction rules. It is the first demonstration of unconscious processing of poetic constructs by the brain.
Imagine being able to view microscopic aspects of a classical nova, a massive stellar explosion on the surface of a white dwarf star (about as big as Earth), in a laboratory rather than from afar via a telescope. Cosmic detonations of this scale and larger created many of the atoms in our bodies. A safe way to study these events in laboratories on Earth is to investigate the exotic nuclei or 'rare isotopes' that influence them.
A new computer model could help policy makers choose the best intervention strategies to rapidly contain an infectious disease outbreak. The model is based on the dynamics of disease transmission across different environments and social settings, and provides critical information about how to mitigate infection, monitor risk and trace disease during a pandemic.
A scientist who has been involved with nearly every aspect of the development and ultimate success of the Laser Interferometer Gravitational-wave Observatory (LIGO), will give a talk about the project's historic detection of gravitational waves.
Does a stay in the intensive care unit give patients a better chance of surviving a chronic obstructive pulmonary disease (COPD) or heart failure flare-up or even a heart attack, compared with care in another type of hospital unit? Unless a patient is clearly critically ill, the answer may be no, according to researchers who analyzed more than 1.5 million Medicare records.
Mothers who want the benefits of breast milk for their babies but can't produce the substance often turn to milk-sharing networks. A new study has found that although not a recommended practice, those who participate in milk-sharing networks generally follow good hygiene, which is critical for keeping milk free from bacterial contamination.
Receiving advice on limiting salt consumption helped kidney disease patients lower their systolic blood pressure by an average of 11 mmHg, research concludes. Limiting salt intake also reduced excess fluid retention that is common among patients with kidney disease.
In a new study, researchers found for the first time that the neurotransmitter dopamine is involved in human bonding, bringing the brain's reward system into our understanding of how we form human attachments. The results, based on a study with 19 mother-infant pairs, have important implications for therapies addressing postpartum depression as well as disorders of the dopamine system such as Parkinson's disease, addiction, and social dysfunction.
Lower levels of vitamin D in the blood increase the risk of clinical relapse in patients with Ulcerative Colitis (UC), an inflammatory bowel disease that causes long-lasting inflammation and ulcers in the colon, a new study has found.
Hens that do not produce their own chicks have been developed for use as surrogates to lay eggs from rare breeds. The advance -- using gene-editing techniques -- could help to boost breeding of endangered birds, as well as improving production of commercial hens, researchers say.
Accurately modeling climate change and interactive human factors -- including inequality, consumption, and population -- is essential for the effective science-based policies and measures needed to benefit and sustain current and future generations. A recent study presents extensive evidence of the need for a new paradigm of modeling that fully incorporates the feedbacks between Earth systems and human systems.
Animal scientist say that gene editing -- following in the footsteps of traditional breeding -- has tremendous potential to boost the sustainability of livestock production, while also enhancing food-animal health and welfare.
Capitalizing on previous studies in self-powered chemo-mechanical movement, researchers have developed a novel method of transporting particles that utilizes chemical reactions to drive fluid flow within microfluidic devices.
Society faces enormous challenges in constructing high-quality, future-oriented built environments. Construction sites today look much like the building sites did at the beginning of the 20th century. Current research on digital fabrication in architecture indicates that the development and integration of innovative digital technologies within architectural and construction processes could transform the building industry -- on the verge of a building industry 4.0. Digital technologies in archite
Biomedical engineers have developed imaging technology that is the first to see DNA 'blink,' or fluoresce. The tool enables researchers to study individual biomolecules (DNA, chromatin, proteins) as well as important global patterns of gene expression, which could yield insights into cancer.
Researchers have developed a novel workflow combining machine learning and density functional theory calculations to create design guidelines for new materials that exhibit useful electronic properties, such as ferroelectricity and piezoelectricity.
Microbiologists have found a yeast in the gut of new babies in Ecuador that appears to be a strong predictor that they will develop asthma in childhood. The new research furthers our understanding of the role microscopic organisms play in our overall health.
Plant specimens stored in herbaria are being used to explore important ecological questions. Researchers have now shown the effectiveness of herbarium specimens of herbaceous plants to track changes in heavy metal concentrations over time. The study compares concentrations of copper, lead, and zinc in specimens collected around Providence, RI, from 1846 to 1916, and compares these levels to plants collected from the same areas in 2015.
New research provides compelling evidence that a group of strange-looking fish living near the mouth of the Congo River are evolving due to the intense hydraulics of the river's rapids and deep canyons. The study reveals that fishes in this part of the river live in 'neighborhoods' that are separated from one another by the waters' turbulent flow.
A longtime anthropology professor who studies violence among prehistoric people in California has published his work, outlining that there are two views related to the origins of violence and warfare in humans. One view suggests that humans in earlier times were peaceful and lived in harmony, and a second view that there has always been competition for resources, war and violence.
The community of microorganisms that resides in the gut, known as the microbiome, has been shown to work in tandem with the genes of a host organism to regulate insulin secretion, a key variable in the onset of the metabolic disease diabetes, new research has found.
A new paper argues that everything else being equal, the complexity of a country's exports also correlates with its degree of economic equality: The more complex a country's products, the greater equality it enjoys relative to similar-sized countries with similar-sized economies.
About 2 percent of domestic-violence incidents involve guns, according to new research. Victims of these crimes typically have fewer injuries but more fear. These findings come as part of her latest work, which looks at how frequently guns and other weapon types appear in domestic-violence incidents.
Screen time before bed can mess with your sleep. But people without TV and laptops skimp on sleep too, researchers say. A study of people living without electricity or artificial light in a remote farming village in Madagascar finds they get shorter, poorer sleep than people in the US or Europe. But they seem to make up for lost shuteye with a more regular sleep routine, the researchers report.
Researchers have developed a new, automated platform capable of returning in-depth analyses of MRI scans in a matter of minutes, rather than hours or days. The system has the potential to minimize patient callbacks, save millions annually, and advance precision medicine.
Researchers present a new method that should enable controlled drug delivery into the bloodstream using DNA computers. The team developed the first DNA computer capable of detecting several antibodies in the blood and performing subsequent calculations based on this input. This is an important step towards the development of smart, 'intelligent' drugs that may allow better control of medication with fewer side-effects and at lower cost.
A gold catalyst can be delivered to a target organ in a higher organism where it performs a chemical transformation visualized by bioimaging. This intriguing approach could make organometallic catalysis applicable for therapy or diagnostics.
In bitter cold regions like northwestern Canada, permafrost has preserved relict ground-ice and vast glacial sedimentary stores in a quasi-stable state. These landscapes therefore retain a high potential for climate-driven transformation, say researchers.
The global commodity trade is a complex system where its network structure, which may arise from bilateral and multilateral agreements, affects its growth and resilience. At time of economic shocks, redundancy in this system is vital to the resilience of growth.
Animals that feed almost solely on nectar, which doesn't produce protective antioxidants, are still able to avoid experiencing oxidative damage to their muscles through a clever adaption that involves converting carbohydrates into antioxidants, a new study reveals.
Researchers have developed an improved type of electrode that is more durable, lasts longer in the body and transmits a clearer, more robust signal than electrodes made from current state-of-the-art materials. This could allow for improved restoration of mobility after spinal cord accidents, as well as improved powered prosthetic limbs.
Researchers have discovered a faster and more efficient gait, never observed in nature, for six-legged robots walking on flat ground. Bio-inspired gaits -- less efficient for robots -- are used by real insects since they have adhesive pads to walk in three dimensions. The results provide novel approaches for roboticists and new information to biologists.
The distribution of normal matter precisely determines gravitational acceleration in all common types of galaxies, a team of researchers reports. This provides further support that the relation is tantamount to a new natural law, the researchers say.
Many who have a chronic traumatic brain injury (TBI) report struggling to solve problems, understand complex information and maintain friendships, despite scoring normally on cognitive tests. New research finds that a gist reasoning test, developed by clinicians and cognitive neuroscientists, is more sensitive than other traditional tests at identifying certain cognitive deficits.
Impaired movement control may result in chronic lower back pain. A new study shows that the combination of manual therapy and exercise is an excellent way to combat movement control impairment in the lower back. This combination reduced the disability experienced by patients and significantly improved their functional ability. A personally tailored exercise program was more beneficial for patients than a generic one, and the treatment results also persisted at a 12-month follow-up.
A team of researchers has developed a new computer-assisted recognition system that can identify individual lemurs in the wild by their facial characteristics and ultimately help to build a database for long-term research on lemur species.
Researchers have created a novel model that shows the step-by-step progression from normal blood cells to leukemia and its precursor diseases, creating replicas of the stages of the disease to test the efficacy of therapeutic interventions at each stage, according to a study. This research marked the first time scientists have been able to transplant leukemia from humans to a test tube and then into mice for study.
A collaboration between chemists and gene therapy experts produced a new way of inserting the code for modified proteins into the cells of mice. If successful in humans, the technique could be useful for vaccines or cancer therapies.
Researchers examine the life history of the Eastern Massasauga rattlesnake, revealing important local climate impacts on the snake that should be carefully weighed when developing conservation strategies. The Eastern Massasauga is a small North American rattler with a distribution centered around the Great Lakes. In 2016, the snake was listed as threatened under the US Endangered Species Act.
The cutting-edge biocompatible near-infrared 3-D tracking system used to guide the suturing in the first smart tissue autonomous robot (STAR) surgery has the potential to improve manual and robot-assisted surgery and interventions through unobstructed 3-D visibility and enhanced accuracy, according to a new study.
Scientists have mapped a vast spider web of interactions between proteins in lung cancer cells, as part of an effort to reach what was considered 'undruggable.' This approach revealed new ways to target cells carrying mutations in cancer-causing genes.
A team has found a way to identify the small population of circulating helper T cells present in the blood after an annual flu vaccine to monitor their contribution to antibody strength. A technique that identifies these helper immune cells could inform future vaccine design, especially for vulnerable populations.
Adult stem cells collected directly from human fat are more stable than other cells -- such as fibroblasts from the skin -- and have the potential for use in anti-aging treatments, according to researchers.
Scientists have discovered that a common type of cell within the human reproductive and intestinal tracts assists HIV in infecting immune cells. Understanding how these cells aid HIV could lead to new methods that prevent HIV transmission.
Experimental evidence confirms what surveys have long suggested: Physicians are more likely to prescribe antibiotics when they believe there is a high expectation of it from their patients, even if they think the probability of bacterial infection is low and antibiotics would not be effective, according to a study.
A study reveals the operation of the biochemical clockwork that drives cellular division in bacteria in extreme detail. It is s an important step forward in research on bacterial growth and could inform efforts to develop drugs that combat antibiotic-resistant bacteria.
You might think that polar bears — and the potential for attack — are the biggest danger the Norwegian arctic island archipelago of Svalbard. But avalanches kill far more people on Svalbard than polar bears ever have. Researchers are working on ways to improve avalanche prediction and protection in the Arctic.
It is not the brain that determines if people are right or left-handed, but the spinal cord, new research indicates. The biopsychologists have demonstrated that gene activity in the spinal cord is asymmetrical already in the womb.
Nonsense-mediated RNA decay (NMD) is a processing pathway in cells that, like a broom, cleans up erroneous RNA. Biomedical scientists report that they have come up with a method in the lab that detects NMD efficiency inside the cell.
Roads are causing rapid evolutionary change in wild populations of plants and animals according to a new paper. The study looks at the evolutionary changes that are being caused by the way roads slice and dice our planet.
Scientists have known for decades that drastically restricting certain nutrients without causing malnutrition prolongs health and lifespan in a wide range of species, but the molecular mechanisms underlying this effect have remained a mystery. Now new research sheds light on an important genetic pathway underlying this effect, raising the possibility that therapies can be developed to prolong healthy human lifespan.
An ultrafast high-contrast camera has been developed that could help self-driving cars and drones see better in extreme road conditions and in bad weather. Unlike typical optical cameras, which can be blinded by bright light and unable to make out details in the dark, this new smart camera can record the slightest movements and objects in real time.
Getting a tattoo may hurt, but giving one is no picnic, either. That's the finding of the first study ever to directly measure the physical stresses that lead to aches and pains in tattoo artists -- workers who support a multibillion-dollar American industry, but who often don't have access to workers' compensation if they get injured.
Women with early-stage breast cancer who had an intermediate risk recurrence score (RS) from a 21-gene expression assay had similar outcomes, regardless of whether they received chemotherapy, a new study has found.
Postmenopausal estrogen-based hormone therapy lasting longer than ten years was associated with a decreased risk of Alzheimer's disease in a large study. The study explored the association between postmenopausal hormone replacement therapy, Alzheimer's disease, dementia and cognition in two nation-wide case-control studies and two longitudinal cohort studies. The largest study comprised approximately 230,000 Finnish women and the follow-up time in different studies was up to 20 years.
Linguistic anthropologists are applying the latest technology to an ancient mystery: how and when early humans inhabited the New World. Their new research suggests complex patterns of contact and migration among the early peoples who first settled the Americas.
The global proliferation of overweight and obese people and people with type 2 diabetes is often associated with the consumption of saturated fats. Scientists have found that even the one-off consumption of a greater amount of palm oil reduces the body's sensitivity to insulin and causes increased fat deposits as well as changes in the energy metabolism of the liver.
Tumors that originate in other organs of the body and spread to the brain are known as metastatic brain tumors. According to the American Brain Tumor Association, this tumor type is the most common in adults, affecting as many as 300,000 people each year. Researchers compared two common postsurgical therapies for metastatic brain tumors and found that stereotactic radiosurgery can provide better outcomes for patients compared to whole-brain radiation.
Outdoor air pollution has been linked to 2.7 million preterm births per year, a major study has concluded. When a baby is born preterm (at less than 37 weeks of gestation), there is an increased risk of death or long-term physical and neurological disabilities.
The evolution of cells and organisms is thought to have been preceded by a phase in which informational molecules like DNA could be replicated selectively. New work shows that hairpin structures make particularly effective DNA replicators.
Hidden in the development of opossums is one possible version of the evolutionary path that led from the simple ears of reptiles to the more elaborative and sensitive structures of mammals, including humans, animal scientists have discovered.